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Alvameline

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Chemical compound

Pharmaceutical compound

Alvameline
Clinical data

ATC code	None
Identifiers
IUPAC name 3-(2-ethyltetrazol-5-yl)-1-methyl-5,6-dihydro-2H-pyridine
CAS Number	120241-31-8^Y
PubChemCID	178030
ChemSpider	154980^Y
UNII	4XFD7B36M6
ChEMBL	ChEMBL131428^Y
CompTox Dashboard(EPA)	DTXSID30152748
Chemical and physical data
Formula	C₉H₁₅N₅
Molar mass	193.254 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES n1nn(nc1\C2=C\CCN(C)C2)CC
InChI InChI=1S/C9H15N5/c1-3-14-11-9(10-12-14)8-5-4-6-13(2)7-8/h5H,3-4,6-7H2,1-2H3^Y Key:RNMOMKCRCIRYCZ-UHFFFAOYSA-N^Y
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Alvameline (Lu 25-109) is aM₁ receptor agonist andM₂/M₃ receptor antagonist^[1] that was under investigation for the treatment ofAlzheimer's disease, but produced poor results inclinical trials^[2] and was subsequently discontinued.

^Sánchez C, Arnt J, Didriksen M, Dragsted N, Moltzen Lenz S, Matz J (June 1998)."In vivo muscarinic cholinergic mediated effects of Lu 25-109, a M1 agonist and M2/M3 antagonist in vitro".Psychopharmacology.137 (3):233–240.doi:10.1007/s002130050615.PMID 9683000.S2CID 20740372. Archived fromthe original on 2000-10-02. Retrieved2009-12-03.
^Sramek JJ, Forrest M, Mengel H, Jhee SS, Hourani J, Cutler NR (1998). "A bridging study of LU 25-109 in patients with probable Alzheimer's disease".Life Sciences.62 (3):195–202.doi:10.1016/S0024-3205(97)01087-4.PMID 9488097.

v t e Psychoanaleptics: Anti-dementia agents (ATC codeN06D and others)
AChE inhibitor medications	Benzgalantamine Donepezil (+memantine) Galantamine Ipidacrine Rivastigmine Tacrine
Other medications	Aducanumab Bifemelane Donanemab Ginkgo folium Lecanemab Meclofenoxate (centrophenoxine) Memantine (+donepezil) Nicergoline
ExperimentalBACE inhibitors	Lanabecestat Verubecestat