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α-Pyrrolidinohexiophenone

From Wikipedia, the free encyclopedia
(Redirected fromAlpha-Pyrrolidinohexiophenone)
Stimulant drug
Pharmaceutical compound
α-Pyrrolidinohexiophenone
Clinical data
Routes of
administration
Oral, intranasal, vaporization, intravenous, rectal, sublingual, subcutaneous
Legal status
Legal status
Identifiers
  • (RS)-1-Phenyl-2-(pyrrolidin-1-yl)hexan-1-one
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC16H23NO
Molar mass245.366 g·mol−1
3D model (JSmol)
  • C1(=CC=CC=C1)C(C(CCCC)N2CCCC2)=O
  • InChI=1S/C16H23NO/c1-2-3-11-15(17-12-7-8-13-17)16(18)14-9-5-4-6-10-14/h4-6,9-10,15H,2-3,7-8,11-13H2,1H3
  • Key:KYIJLDDXQWBNGX-UHFFFAOYSA-N

α-Pyrrolidinohexiophenone (α-PHP,A-PHP,Aphp,alpha-PHP,α-Pyrrolidinohexanophenone,PV-7) is a syntheticstimulant drug of thecathinone class developed in the 1960s[2] which has been reported as a noveldesigner drug.[3][4][5][6][7]

Similar chemical compounds

[edit]

α-Pyrrolidinohexiophenone is a longer chain homologue ofα-PVP, having an extra carbon on the alkyl side chain. Regarding the potency of alpha-PHP in the brain, chemist Michael H. Baumann of the Designer Drug Research Unit (established by Baumann[8]) of theNational Institute on Drug Abuse stated: "alpha-PHP might be even more potent than alpha-PVP"; this statement is based on laboratory tests of chemical reactivity.[9]

Pyrovalerone is astructural isomer of alpha-PHP.[10]

Legality

[edit]

The President of the Republic of Italy classifiedcathinone and all structurally derived analogues (includingpyrovalerone analogues) as narcotics in January 2012.[11][12]

Sweden's public health agency suggested to classify α-PHP as narcotic on June 1, 2015.[13]

As of October 2015, α-PHP is a controlled substance in China.[14]

In December 2019, theUNODC announced scheduling recommendations placing Alpha-PHP into Schedule II.[15]

As of 29 October 2021, α-PHP has been banned in the Netherlands under the 1971 Vienna Convention on Psychotropic Substances.[16]

In the US, a-PHP is a Schedule I controlled substance as of 2022.[17]

See also

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References

[edit]
  1. ^Anvisa (2023-07-24)."RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).Diário Oficial da União (published 2023-07-25).Archived from the original on 2023-08-27. Retrieved2023-08-27.
  2. ^US patent 3314970, Ernst Seeger, "α-Pyrrolidino ketones", published 1967-04-18, issued 1967-04-18, assigned to Boehringer Lagelheim G.m.b.H. 
  3. ^Uchiyama N, Shimokawa Y, Kawamura M, Kikura-Hanajiri R, Hakamatsuka T (August 2014). "Chemical analysis of a benzofuran derivative, 2-(2-ethylaminopropyl)benzofuran (2-EAPB), eight synthetic cannabinoids, five cathinone derivatives, and five other designer drugs newly detected in illegal products".Forensic Toxicology.32 (2):266–281.doi:10.1007/s11419-014-0238-5.S2CID 11873421.
  4. ^Majchrzak M, Rojkiewicz M, Celiński R, Kuś P, Sajewicz M (October 2015)."Identification and characterization of new designer drug 4-fluoro-PV9 and α-PHP in the seized materials".Forensic Toxicology.34:115–124.doi:10.1007/s11419-015-0295-4.PMC 4705138.PMID 26793278.
  5. ^Paul M, Bleicher S, Guber S, Ippisch J, Polettini A, Schultis W (November 2015). "Identification of phase I and II metabolites of the new designer drug α-pyrrolidinohexiophenone (α-PHP) in human urine by liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS)".Journal of Mass Spectrometry.50 (11):1305–1317.Bibcode:2015JMSp...50.1305P.doi:10.1002/jms.3642.PMID 26505776.
  6. ^Klavž J, Gorenjak M, Marinšek M (August 2016). "Suicide attempt with a mix of synthetic cannabinoids and synthetic cathinones: Case report of non-fatal intoxication with AB-CHMINACA, AB-FUBINACA, alpha-PHP, alpha-PVP and 4-CMC".Forensic Science International.265:121–124.doi:10.1016/j.forsciint.2016.01.018.PMID 26890319.
  7. ^Grapp M, Kaufmann C, Schwelm HM, Neukamm MA (March 2023). "Toxicological Investigation of a Case Series Involving the Synthetic Cathinone α-Pyrrolidinohexiophenone (α-PHP) and Identification of Phase I and II Metabolites in Human Urine".Journal of Analytical Toxicology.47 (2):162–174.doi:10.1093/jat/bkac057.PMID 35921233.
  8. ^"NIDA IRP - Michael Baumann, Ph.D."Archived from the original on 2018-12-26. Retrieved2018-12-25.
  9. ^Wise J (30 September 2016)."The Obscure, Legal Drug That Fuels John McAfee".New York Magazine. Archived fromthe original on 2021-01-21.
  10. ^Meltzer PC, Butler D, Deschamps JR, Madras BK (February 2006)."1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors".Journal of Medicinal Chemistry.49 (4):1420–1432.doi:10.1021/jm050797a.PMC 2602954.PMID 16480278.
  11. ^"Decreto 29 dicembre 2011 (12A00013) (G.U. Serie Generale n. 3 del 4 gennaio 2012)"(PDF). Archived fromthe original(PDF) on 2016-07-01.
  12. ^"EMCDDA–Europol Joint Report on a new psychoactive substance: 1-phenyl-2-(1-pyrrolidinyl)-1-pentanone (α-PVP)". European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). September 2015.Archived from the original on 2016-06-05. Retrieved2016-05-28.
  13. ^"23 nya ämnen kan klassas som narkotika eller hälsofarlig vara".Archived from the original on 1 July 2015. Retrieved29 June 2015.
  14. ^"关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Archived fromthe original on 2015-10-01.
  15. ^"December 2019 – WHO: World Health Organization recommends 12 NPS for scheduling".Archived from the original on 2020-09-26. Retrieved2021-05-31.
  16. ^"Verdrag inzake psychotrope stoffen".Tractatenblad van het Koninkrijk der Nederlanden.77 (7). 21 February 1971.Archived from the original on 2021-09-28. Retrieved2021-10-29.
  17. ^Milgram, Anne (June 2022)."Schedules of Controlled Substances: Placement of N-Ethylhexedrone, alpha-Pyrrolidinohexanophenone, 4-Methyl-alpha-ethylaminopentiophenone, 4′-Methyl-alpha-pyrrolidinohexiophenone, alpha-Pyrrolidinoheptaphenone, and 4′-Chloro-alpha-pyrrolidinovalerophenone in Schedule I".Federal Register.Drug Enforcement Administration. Retrieved2024-04-23.
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