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α-Neoendorphin

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(Redirected fromAlpha-Neoendorphin)
α-Neoendorphin
Names
Other names
Alpha-Neoendorphin
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
KEGG
  • InChI=1S/C60H89N15O13/c1-36(2)30-46(73-56(84)47(32-37-12-4-3-5-13-37)69-51(79)35-67-50(78)34-68-52(80)42(63)31-38-18-22-40(76)23-19-38)55(83)71-44(16-10-28-66-60(64)65)53(81)70-43(14-6-8-26-61)54(82)74-48(33-39-20-24-41(77)25-21-39)58(86)75-29-11-17-49(75)57(85)72-45(59(87)88)15-7-9-27-62/h3-5,12-13,18-25,36,42-49,76-77H,6-11,14-17,26-35,61-63H2,1-2H3,(H,67,78)(H,68,80)(H,69,79)(H,70,81)(H,71,83)(H,72,85)(H,73,84)(H,74,82)(H,87,88)(H4,64,65,66)/t42-,43-,44-,45-,46-,47-,48-,49-/m0/s1
    Key: KZTDMJBCZSGHOG-XJIZABAQSA-N
  • N[C@@H](CC1=CC=C(O)C=C1)C(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC3=CC=C(O)C=C3)C(N4CCC[C@H]4C(N[C@H](C(O)=O)CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O
Properties
C60H89N15O13
Molar mass1228.464 g·mol−1
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
Chemical compound

α-Neoendorphin is anendogenousopioid peptide with adecapeptide structure and theamino acid sequenceTyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro-Lys.[1]

α-Neoendorphin is aneuropeptide.Prodynorphin or Proenkephalin B is its precursor. Researchers and anatomists have not yet studied the distribution of α-neoendorphin in the human in detail. However, some studies have been done which supports the presence of α-neoendorphinimmunoreactive fibers throughout the human brainstem. According to a study done by Duque, Ewing, Arturo Mangas, Pablo Salinas, Zaida Díaz-cabiale, José Narváez, and Rafael Coveñas; α-neoendorphin immunoreactive fibers can be found in the caudal part of the solitary nucleus, in the caudal and the gelatinosa parts of the spinal trigeminal nucleus, and only low density was found in the central grey matter of medulla.[2]

See also

[edit]

References

[edit]
  1. ^Kangawa K.; Minamino N.; Chino N (1981). "The complete amino acid sequence of α-neo-endorphin".Biochemical and Biophysical Research Communications.99 (3):871–878.doi:10.1016/0006-291X(81)91244-4.PMID 7247946.
  2. ^Duque, Ewing; Mangas, Arturo; Salinas, Pablo; Díaz-Cabiale, Zaida; Narváez, José Angel; Coveñas, Rafael (2012-02-09). "Mapping of alpha-neo-endorphin- and neurokinin B-immunoreactivity in the human brainstem".Brain Structure and Function.218 (1):131–149.doi:10.1007/s00429-012-0388-3.ISSN 1863-2653.PMID 22318412.S2CID 253974523.


Hormones
Opioid peptides
Dynorphins
Endomorphins
Endorphins
Enkephalins
Others
Other
neuropeptides
Kinins
Neuromedins
Orexins
Other
μ-opioid
(MOR)
Agonists
(abridged;
full list)
Antagonists
δ-opioid
(DOR)
Agonists
Antagonists
κ-opioid
(KOR)
Agonists
Antagonists
Nociceptin
(NOP)
Agonists
Antagonists
Others


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