Thealpha-1B adrenergic receptor (α1B-adrenoreceptor), also known asADRA1B, is analpha-1 adrenergic receptor, and also denotes the humangene encoding it.[5] The crystal structure of the α1B-adrenergic receptor has been determined in complex with the inverse agonist (+)-cyclazosin.[6]
There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.
This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as aprotooncogene. This gene comprises 2exons and a single large intron of at least 20 kb that interrupts the coding region.[5]
Alpha-1B adrenergic receptor has been shown tointeract withAP2M1.[8] A role in regulation of dopaminergic neurotransmission has also been suggested.[9][10]
Schwinn DA, Johnston GI, Page SO, et al. (1995). "Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues".J. Pharmacol. Exp. Ther.272 (1):134–42.PMID7815325.
Weinberg DH, Trivedi P, Tan CP, et al. (1994). "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c".Biochem. Biophys. Res. Commun.201 (3):1296–304.doi:10.1006/bbrc.1994.1845.PMID8024574.
Forray C, Bard JA, Wetzel JM, et al. (1994). "The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype".Mol. Pharmacol.45 (4):703–8.PMID8183249.
Qian A, Wang W, Sanborn BM (1998). "Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11)".Cell. Signal.10 (2):101–5.doi:10.1016/S0898-6568(97)00097-1.PMID9481484.
Sasaguri T, Teruya H, Ishida A, et al. (2000). "Linkage between alpha(1) adrenergic receptor and the Jak/STAT signaling pathway in vascular smooth muscle cells".Biochem. Biophys. Res. Commun.268 (1):25–30.doi:10.1006/bbrc.1999.2066.PMID10652206.
Gonzalez-Cabrera PJ, Gaivin RJ, Yun J, et al. (2003). "Genetic profiling of alpha 1-adrenergic receptor subtypes by oligonucleotide microarrays: coupling to interleukin-6 secretion but differences in STAT3 phosphorylation and gp-130".Mol. Pharmacol.63 (5):1104–16.doi:10.1124/mol.63.5.1104.PMID12695539.S2CID10868191.
Pupo AS, Minneman KP (2004). "Specific interactions between gC1qR and alpha1-adrenoceptor subtypes".J. Recept. Signal Transduct. Res.23 (2–3):185–95.doi:10.1081/RRS-120025200.PMID14626446.S2CID29600903.
Zhang T, Xu Q, Chen FR, et al. (2005). "Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors".Acta Pharmacol. Sin.25 (11):1471–8.PMID15525470.
