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Almokalant

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Chemical compound

Pharmaceutical compound

Almokalant
Clinical data

ATC code	None
Identifiers
IUPAC name 4-(3-{Ethyl[3-(propane-1-sulfinyl)propyl]amino}-2-hydroxypropoxy)benzonitrile
CAS Number	123955-10-2^Y
PubChemCID	3033962
ChemSpider	2298526^Y
UNII	I9NG89L275
ChEMBL	ChEMBL362103^Y
CompTox Dashboard(EPA)	DTXSID40869693
Chemical and physical data
Formula	C₁₈H₂₈N₂O₃S
Molar mass	352.49 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=S(CCC)CCCN(CC)CC(O)COc1ccc(C#N)cc1
InChI InChI=1S/C18H28N2O3S/c1-3-11-24(22)12-5-10-20(4-2)14-17(21)15-23-18-8-6-16(13-19)7-9-18/h6-9,17,21H,3-5,10-12,14-15H2,1-2H3^Y Key:ZMHOBBKJBYLXFR-UHFFFAOYSA-N^Y
(verify)

Almokalant is adrug used to treatarrhythmia.^[1] It is apotassium channel blocker.^[1] It has been found to haveteratogenic effects in rats.^[2]

^^a ^bWiesfeld AC, Crijns HJ, Bergstrand RH, Almgren O, Hillege HL, Lie KI (October 1993). "Torsades de pointes with Almokalant, a new class III antiarrhythmic drug".American Heart Journal.126 (4):1008–1011.doi:10.1016/0002-8703(93)90726-p.PMID 8213422.
^Wellfelt K, Sköld AC, Wallin A, Danielsson BR (1999-04-01). "Teratogenicity of the class III antiarrhythmic drug almokalant. Role of hypoxia and reactive oxygen species".Reproductive Toxicology.13 (2):93–101.Bibcode:1999RepTx..13...93W.doi:10.1016/s0890-6238(98)00066-5.PMID 10213516.

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