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| Other names | Alfetadrine; Aletamine; α-Allylphenethylamine; α-Allyl-β-phenylethylamine |
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| Formula | C11H15N |
| Molar mass | 161.248 g·mol−1 |
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Alfetamine, orα-allyl-phenethylamine, is a chemical compound of thephenethylamine family. It was briefly investigated as a possible antidepressant in the early 1970s. Its activity profile was said to be very similar toimipramine andamitriptyline, twotricyclic antidepressants.[1] It has now been largely superseded by the newer compounds in this class, and only rarely found in scientific literature. The "alpha" in its name refers to its prodrug form, alfetamine. In addition to being an antidepressant, alfetamine is also a neuroprotective agent that acts as a weak dopamine antagonist and a high affinity κ-opioid receptor agonist.[medical citation needed]
Alfetamine was synthesized by Kenji Tsukada and colleagues at Shinshu University and Dow Chemical Company in the 1960s and early 1970s.
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