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| Names | |
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| Other names Vincamajoridine | |
| Identifiers | |
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| Properties | |
| C22H26N2O4 | |
| Molar mass | 382.460 g·mol−1 |
| Melting point | 225 °C (437 °F; 498 K)[1] |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Akuammine (vincamajoridine[2]) is anindole alkaloid. It is the most abundant alkaloid found in the seeds from the treePicralima nitida,[3] commonly known as akuamma, comprising 0.56% of the dried powder. It has also been isolated fromVinca major.[2] Akuammine is structurally related toyohimbine,mitragynine and more distantlyVoacangine, all of which are alkaloid plant products with pharmacological properties.
Akuammine hasantimalarial activity,[3] and may be the primary constituent ofP. nitida seeds responsible for this activity.[4]
Akuammine is anopioid agonist with low affinity, selective for themu-opioid receptor, when testedin vitro.[5][6]
