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Aglepristone

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Aglepristone
Clinical data
Trade namesAlizin
Other namesRU-46534; RU-534; 11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17α-[(Z)-propenyl]estra-4,9-dien-3-one
Drug classAntiprogestogen;Antiglucocorticoid
ATC code
Identifiers
  • (8S,11R,13S,14S,17R)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-[(Z)-prop-1-enyl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.211.372Edit this at Wikidata
Chemical and physical data
FormulaC29H37NO2
Molar mass431.620 g·mol−1
3D model (JSmol)
  • C/C=C\[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)O
  • InChI=1S/C29H37NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h5-7,9-10,15,17,24-26,32H,8,11-14,16,18H2,1-4H3/b15-5-/t24-,25+,26-,28-,29-/m0/s1
  • Key:RTCKAOKDXNYXEH-FWSJOHTJSA-N

Aglepristone (INNTooltip International Nonproprietary Name) (brand nameAlizin; former developmental code namesRU-46534,RU-534) is asynthetic,steroidalantiprogestogen related tomifepristone.[1][2][3] Aglepristone, similarly to mifepristone, also possesses someantiglucocorticoid activity.[4][5]Aglepristone is used as anabortifacent, to induceparturition, and as a treatment formammary hyperplasia andpyometra. It is only used in cats and dogs.[6]

See also

[edit]

References

[edit]
  1. ^Kaufman LK, Baldwin CJ (1 December 2013)."Pregnancy Loss in the Bitch and Queen". In Bonagura JD, Twedt DC (eds.).Kirk's Current Veterinary Therapy XV. Elsevier Health Sciences. pp. 3009–.ISBN 978-0-323-22762-9.
  2. ^Squires EJ (2010)."Endocrine manipulation of reproduction.".Applied Animal Endocrinology. CABI. pp. 207–.ISBN 978-1-84593-755-3.
  3. ^Papich MC (3 November 2010)."Aglepristone".Saunders Handbook of Veterinary Drugs: Small and Large Animal. Elsevier Health Sciences. pp. 120–.ISBN 978-1-4377-0192-0.
  4. ^Batista M, Reyes R, Santana M, Alamo D, Vilar J, González F, et al. (October 2011). "Induction of parturition with aglepristone in the Majorera goat".Reproduction in Domestic Animals = Zuchthygiene.46 (5):882–888.doi:10.1111/j.1439-0531.2011.01759.x.PMID 21320179.
  5. ^Baan M, Taverne MA, de Gier J, Kooistra HS, Kindahl H, Dieleman SJ, Okkens AC (March 2008). "Hormonal changes in spontaneous and aglépristone-induced parturition in dogs".Theriogenology.69 (4):399–407.doi:10.1016/j.theriogenology.2007.10.008.PMID 18054071.
  6. ^Papich, Mark (2016).Saunders Handbook of Veterinary Drugs (4th ed.). Elsevier.ISBN 978-0-323-24485-5.
Progestogens
(andprogestins)
PRTooltip Progesterone receptoragonists
Antiprogestogens
SPRMsTooltip Selective progesterone receptor modulators
PRTooltip Progesterone receptorantagonists
GRTooltip Glucocorticoid receptor
Agonists
Mixed
(SEGRMsTooltip Selective glucocorticoid receptor agonists)
Antagonists
Others
PRTooltip Progesterone receptor
Agonists
Mixed
(SPRMsTooltip Selective progesterone receptor modulators)
Antagonists
mPRTooltip Membrane progesterone receptor
(PAQRTooltip Progestin and adipoQ receptor)
Agonists
Antagonists
Other sex hormones and modulators of the genital system (G03X)
Antigonadotropins (G03XA)
Antiprogestogens (G03XB)
Selective estrogen
receptor modulators (G03XC)
Others (G03XX)
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