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| Names | |
|---|---|
| IUPAC name L-Tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl-L-arginyl-L-valinamide | |
| Identifiers | |
3D model (JSmol) | |
| ChemSpider |
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| Properties | |
| C44H69N15O9S | |
| Molar mass | 984.18 g/mol |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Adrenorphin, also sometimes referred to asmetorphamide, is anendogenous,C-terminallyamidated,opioidoctapeptide (Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2, YGGFMRRV-NH2) that is produced fromproteolyticcleavage ofproenkephalin A and is widely distributed throughout themammalianbrain.[1][2][3][4][5] It was named based on the fact that it was originally detected inhumanphaeochromocytomatumour derived from theadrenal medulla, and was subsequently found in normal human andbovine adrenal medulla as well.[1] Adrenorphin exhibitspotent opioid activity, acting as a balancedμ- andκ-opioid receptoragonist while having no effects onδ-opioid receptors.[2] It possessesanalgesic andrespiratory depressive properties.[6]
