| Adhes-Ig_like | |||||||
|---|---|---|---|---|---|---|---|
 a reassessment of the madcam-1 structure and its role in integrin recognition. | |||||||
| Identifiers | |||||||
| Symbol | Adhes-Ig_like | ||||||
| Pfam | PF09085 | ||||||
| Pfam clan | CL0159 | ||||||
| InterPro | IPR015169 | ||||||
| SCOP2 | 1gsm /SCOPe /SUPFAM | ||||||
| |||||||
In molecular biology, theadhesin molecule (immunoglobulin-like) is aprotein domain. This domain is found in mucosal vascular addressincell adhesion molecule 1proteins (MAdCAM-1). These arecell adhesionmoleculesexpressed on the endothelium inmucosa that guide the specific homing oflymphocytes into mucosaltissues. MAdCAM-1 belongs to a subclass of theimmunoglobulin superfamily (IgSF), the members of which areligands forintegrins.[1] Thecrystal structure of this domain has been reported; it adopts an immunoglobulin-like beta-sandwich structure, with seven strands arranged in twobeta-sheets in a Greek-key topology.[1][2]