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| Names | |
|---|---|
| Other names ADP ribose ADPR Adenosine 5'-diphosphoribose | |
| Identifiers | |
3D model (JSmol) | |
| ChEMBL | |
| ChemSpider |
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| MeSH | Adenosine+Diphosphate+Ribose |
| UNII | |
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| Properties | |
| C15H23N5O14P2 | |
| Molar mass | 559.316 g/mol |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Adenosine diphosphate ribose (ADPR) is anester molecule formed into chains by the enzymepoly ADP ribose polymerase.[1] ADPR is created fromcyclic ADP-ribose (cADPR) by theCD38 enzyme usingnicotinamide adenine dinucleotide (NAD+) as acofactor.[1]
ADPR binds to and activates theTRPM2 ion channel.[2] ADPR is the most potentagonist of the TRPM2 channel.[3] cADPR also binds to TPRM2, and the action of both molecules issynergistic, with both molecules enhancing the action of the other molecule in activating the TRPM2 channel.[4] Researchers are not sure how the Adenosine diphosphate reacts with the TRPM2 channel, but the ribose sugar may play a role in activating theTRPM2 ion channel.[5]
Researchers believe that co-targeting DNA-dependent protein kinase and poly(adenosine diphosphate-ribose) polymerase-1 does not promote apoptosis or mitotic catastrophe of cancer cells after radiation.[6]
