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Activating protein 2

From Wikipedia, the free encyclopedia
Family of transcription factors
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
Identifiers
SymbolTFAP2A
Alt. symbolsTFAP2, AP2TF
NCBI gene7020
HGNC11742
OMIM107580
RefSeqNM_003220
UniProtP05549
Other data
LocusChr. 6p22.3
Search for
StructuresSwiss-model
DomainsInterPro
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
Identifiers
SymbolTFAP2B
Alt. symbolsAP2-B
NCBI gene7021
HGNC11743
OMIM601601
RefSeqNM_003221
UniProtQ92481
Other data
LocusChr. 6p12
Search for
StructuresSwiss-model
DomainsInterPro
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
Identifiers
SymbolTFAP2C
NCBI gene7022
HGNC11744
OMIM601602
RefSeqNM_003222
UniProtQ92754
Other data
LocusChr. 20q13.2
Search for
StructuresSwiss-model
DomainsInterPro
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
Identifiers
SymbolTFAP2D
Alt. symbolsTFAP2BL1
NCBI gene83741
HGNC15581
OMIM610161
RefSeqNM_172238
UniProtQ7Z6R9
Other data
LocusChr. 6p12.3
Search for
StructuresSwiss-model
DomainsInterPro
transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
Identifiers
SymbolTFAP2E
Alt. symbolsAP2E
NCBI gene339488
HGNC30774
RefSeqNM_178548
UniProtQ6VUC0
Other data
LocusChr. 1p34.3
Search for
StructuresSwiss-model
DomainsInterPro

Activating Protein 2 (AP-2) is a family of closely relatedtranscription factors[1][2] which plays a critical role in regulating gene expression during early development.[3]

References

[edit]
  1. ^Williams T, Tjian R (1991). "Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins".Science.251 (4997):1067–71.Bibcode:1991Sci...251.1067W.doi:10.1126/science.1998122.PMID 1998122.
  2. ^Williams T, Tjian R (1991)."Analysis of the DNA-binding and activation properties of the human transcription factor AP-2".Genes Dev.5 (4):670–82.doi:10.1101/gad.5.4.670.PMID 2010091.
  3. ^Hilger-Eversheim K, Moser M, Schorle H, Buettner R (2000). "Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control".Gene.260 (1–2):1–12.doi:10.1016/S0378-1119(00)00454-6.PMID 11137286.

External links

[edit]
(1) Basic domains
(1.1) Basicleucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3)bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2)Zinc finger DNA-binding domains
(2.1)Nuclear receptor(Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3.1)Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3)Fork head /winged helix
(3.4)Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4)β-Scaffold factors with minor groove contacts
(4.1)Rel homology region
(4.2)STAT
(4.3) p53-like
(4.4)MADS box
(4.6)TATA-binding proteins
(4.7)High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3)Pocket domain
(0.5)AP-2/EREBP-related factors
(0.6) Miscellaneous


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