 | |
| Combination of | |
|---|---|
| Abacavir sulfate | Nucleoside analoguereverse transcriptase inhibitor |
| Lamivudine | Nucleoside analoguereverse transcriptase inhibitor |
| Zidovudine | Nucleoside analoguereverse transcriptase inhibitor |
| Clinical data | |
| Trade names | Trizivir |
| AHFS/Drugs.com | Professional Drug Facts |
| MedlinePlus | a616051 |
| License data | |
| Pregnancy category | |
| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| PubChemCID | |
| ChemSpider |
|
| KEGG |
|
| NIAID ChemDB | |
 N Y (what is this?) (verify) | |
Abacavir/lamivudine/zidovudine, sold under the brand nameTrizivir, is afixed-dose combinationantiretroviral medication for the treatment ofHIV/AIDS.[2][3][4] It contains threereverse transcriptase inhibitors patented byGlaxoSmithKline and marketed by a joint venture withPfizer,ViiV Healthcare:[5]
It is indicated in the treatment ofAIDS/HIV-1.[2] For this purpose, the combination is very useful inpregnant women to decrease the risk ofmother-to-child transmission.[6]
The most common effects include headache and nausea (feeling sick).[3]
Abacavir/lamivudine/zidovudine was approved for use in the United States and the European Union in 2000.[7][3] In December 2013,Lupin Limited launched a generic version of abacavir/lamivudine/zidovudine.[8][9][10]
The most common side effects of abacavir/lamivudine/zidovudine includenausea,vomiting,diarrhea,fatigue,paresthesia andheadache. As with many medications targeting reverse transcriptase,body fat redistribution syndrome may occur, causing body fat to center on the upper back and neck, breast, and torso, and potentially decreasing around the legs, arms, and face.[11]IRIS may occur which is when the immune system initially improves, but then deteriorates as a previously ignored infection becomes active. Other serious side effects include:[12]
| Subsidiaries |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Predecessors, acquisitions | |||||||||
| Products |
| ||||||||
| People |
| ||||||||
| Litigation | |||||||||
| Other | |||||||||
