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AZD-1940

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
AZD-1940
Clinical data
Other namesAZD1940; ART-2713; ART2713; NEO-1940; NEO1940
Routes of
administration		Oral
Legal status
Legal status
Identifiers
  • N-{1-[(4,4-difluorocyclohexyl)methyl]-2-(1,1-dimethylethyl)-1H-benzimidazol-5-yl}ethanesulfonamide
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC20H29F2N3O2S
Molar mass413.53 g·mol−1
3D model (JSmol)
  • CCS(=O)(=O)Nc1ccc2c(c1)nc(n2CC3CCC(CC3)(F)F)C(C)(C)C
  • InChI=1S/C20H29F2N3O2S/c1-5-28(26,27)24-15-6-7-17-16(12-15)23-18(19(2,3)4)25(17)13-14-8-10-20(21,22)11-9-14/h6-7,12,14,24H,5,8-11,13H2,1-4H3
  • Key:ZAGGGZCIFUQHOH-UHFFFAOYSA-N

AZD-1940, also known asART-2713 orNEO-1940, is a drug developed byAstraZeneca, that is a peripherally selectivecannabinoidagonist which binds with high affinity to both the CB1 and CB2 receptors.[1] It was developed for the treatment ofneuropathic pain, but while it showed good peripheral selectivity in animal studies,[2] in humanclinical trials it failed to show sufficient analgesic efficacy and produced unexpectedly strong side effects associated with central cannabinoid activity, and so was discontinued from further development.[3][4]

See also

[edit]

References

[edit]
  1. ^"ART 2713".AdisInsight. 15 September 2025. Retrieved30 September 2025.
  2. ^Schou M, Varnäs K, Jucaite A, Gulyás B, Halldin C, Farde L (April 2013). "Radiolabeling of the cannabinoid receptor agonist AZD1940 with carbon-11 and PET microdosing in non-human primate".Nuclear Medicine and Biology.40 (3):410–4.doi:10.1016/j.nucmedbio.2012.10.011.PMID 23352602.
  3. ^Kalliomäki J, Segerdahl M, Webster L, Reimfelt A, Huizar K, Annas P, et al. (January 2013). "Evaluation of the analgesic efficacy of AZD1940, a novel cannabinoid agonist, on post-operative pain after lower third molar surgical removal".Scandinavian Journal of Pain.4 (1):17–22.doi:10.1016/j.sjpain.2012.08.004.PMID 29913883.S2CID 49302159.
  4. ^Kalliomäki J, Annas P, Huizar K, Clarke C, Zettergren A, Karlsten R, Segerdahl M (March 2013). "Evaluation of the analgesic efficacy and psychoactive effects of AZD1940, a novel peripherally acting cannabinoid agonist, in human capsaicin-induced pain and hyperalgesia".Clinical and Experimental Pharmacology & Physiology.40 (3):212–8.doi:10.1111/1440-1681.12051.PMID 23324098.S2CID 1630384.
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