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AVN-397

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Drug possibly to treat Alzheimer's disease

AVN-397 is a5-hydroxytryptamine subtype 6 receptorantagonist drug developed by Avineuro Pharmaceuticals Inc. that can potentially be used to treatAlzheimer's disease andgeneral anxiety disorder (GAD).[1][2] Avineuro announced that it would startPhase II clinical trials in 2009, and those trials were ongoing as of 2012.[3][4][5]Phase II trials are now listed as Discontinued.[6][7]

References

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  1. ^Griebel, Guy; Holmes, Andrew (2013)."50 years of hurdles and hope in anxiolytic drug discovery".Nature Reviews Drug Discovery.12 (9):667–687.doi:10.1038/nrd4075.ISSN 1474-1776.PMC 4176700.PMID 23989795.S2CID 6531810.
  2. ^"AVN 397 - AdisInsight".adisinsight.springer.com. Retrieved2023-03-12.
  3. ^"Avineuro Announces Beginning Of Phase II Clinical Studies Of AVN-397, Potent Small Molecule For Treatment Of Anxiety And Alzheimer's Disease".BioSpace. Retrieved2023-03-12.
  4. ^Froestl, W.; Pfeifer, A.; Muhs, A. (2014)."Cognitive enhancers (Nootropics). Part 3: drugs interacting with targets other than receptors or enzymes. Disease-modifying drugs. Update 2014".Journal of Alzheimer's Disease.42 (4):1079–1149.doi:10.3233/JAD-141206.PMID 25061058.S2CID 998047. Retrieved2023-03-12.
  5. ^Medicines in Development / Mental Illnesses / 2012 Report(PDF),archived(PDF) from the original on 9 Jul 2022
  6. ^"Search for drugs | Therapeutic Target Database".
  7. ^"Delving into the Latest Updates on AVN-397 with Synapse".synapse.patsnap.com. Retrieved2025-03-08.


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