This gene encodes a component ofvacuolarATPase (V-ATPase), a multisubunit enzyme that mediates acidification ofeukaryotic intracellularorganelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting,zymogen activation, receptor-mediatedendocytosis, andsynaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the regulatory H subunit of the V1 domain which is required for catalysis of ATP but not the assembly of V-ATPase. Three alternatively spliced transcript variants encode two isoforms of the H subunit.[7]
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Nishi T, Forgac M (Feb 2002). "The vacuolar (H+)-ATPases--nature's most versatile proton pumps".Nature Reviews Molecular Cell Biology.3 (2):94–103.doi:10.1038/nrm729.PMID11836511.S2CID21122465.
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