V-type proton ATPase subunit d 1 is anenzyme that in humans is encoded by theATP6V0D1gene.[5][6]
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^van Hille B, Vanek M, Richener H, Green JR, Bilbe G (Jan 1994). "Cloning and tissue distribution of subunits C, D, and E of the human vacuolar H(+)-ATPase".Biochem Biophys Res Commun.197 (1):15–21.doi:10.1006/bbrc.1993.2434.PMID8250920.
Stevens TH, Forgac M (1998). "Structure, function and regulation of the vacuolar (H+)-ATPase".Annu. Rev. Cell Dev. Biol.13 (1):779–808.doi:10.1146/annurev.cellbio.13.1.779.PMID9442887.
Agarwal AK, White PC (2001). "Structure of the VPATPD gene encoding subunit D of the human vacuolar proton ATPase".Biochem. Biophys. Res. Commun.279 (2):543–7.doi:10.1006/bbrc.2000.4003.PMID11118322.
