This gene encodes a component ofvacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification ofeukaryotic intracellularorganelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes asprotein sorting,zymogen activation,receptor-mediated endocytosis, andsynaptic vesicleproton gradient generation. V-ATPase is composed of acytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits, plus the C, D, E, F, and H subunits. The V1 domain contains the ATPcatalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d.
Additionalisoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes, or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain, and is the human counterpart ofyeast VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nishigori H, Yamada S, Tomura H, Fernald AA, Le Beau MM, Takeuchi T, Takeda J (Oct 1998). "Identification and characterization of the gene encoding a second proteolipid subunit of human vacuolar H(+)-ATPase (ATP6F)".Genomics.50 (2):222–8.doi:10.1006/geno.1998.5310.PMID9653649.
Izumi H, Ise T, Murakami T, et al. (2003). "Structural and functional characterization of two human V-ATPase subunit gene promoters".Biochim. Biophys. Acta.1628 (2):97–104.doi:10.1016/S0167-4781(03)00119-2.PMID12890556.
