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Lanicemine

From Wikipedia, the free encyclopedia
(Redirected fromARL-15896-AR)
Chemical compound
Pharmaceutical compound
Lanicemine
Clinical data
ATC code
  • none
Legal status
Legal status
  • Development terminated
Identifiers
  • (1S)-1-Phenyl-2-pyridin-2-ylethanamine
CAS Number
PubChemCID
IUPHAR/BPS
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC13H14N2
Molar mass198.269 g·mol−1
3D model (JSmol)
  • N[C@H](C1=CC=CC=C1)CC2=NC=CC=C2
  • InChI=1S/C13H14N2/c14-13(11-6-2-1-3-7-11)10-12-8-4-5-9-15-12/h1-9,13H,10,14H2/t13-/m0/s1
  • Key:FWUQWDCOOWEXRY-ZDUSSCGKSA-N

Lanicemine (AZD6765) is a low-trappingNMDA receptor antagonist that was underdevelopment byAstraZeneca for the management of severe andtreatment-resistant depression.[1][2] Lanicemine differs fromketamine in that it is alow-trappingNMDA receptor antagonist, showing similar rapid-acting antidepressant effects to ketamine in clinical trials but with little or no psychotomimetic side effects.[3] However, lanicemine did not meet study endpoints, and its development was terminated by AstraZeneca in 2013.[4]

See also

[edit]

References

[edit]
  1. ^"Lanicemine". AdisInsight. Retrieved18 June 2017.
  2. ^Machado-Vieira R, Henter ID, Zarate CA (May 2017)."New targets for rapid antidepressant action".Progress in Neurobiology.152:21–37.doi:10.1016/j.pneurobio.2015.12.001.PMC 4919246.PMID 26724279.
  3. ^Zarate CA, Mathews D, Ibrahim L, Chaves JF, Marquardt C, Ukoh I, et al. (August 2013)."A randomized trial of a low-trapping nonselective N-methyl-D-aspartate channel blocker in major depression".Biological Psychiatry.74 (4):257–64.doi:10.1016/j.biopsych.2012.10.019.PMC 3594049.PMID 23206319.
  4. ^Flowers S."Return to growth: AstraZeneca's CEO Pascal Soriot says 2013 was year of "momentum" for the company". Retrieved6 February 2014.
AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
KARTooltip Kainate receptor
NMDARTooltip N-Methyl-D-aspartate receptor
Retrieved from "https://en.wikipedia.org/w/index.php?title=Lanicemine&oldid=1329166732"
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