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APP-FUBINACA

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
APP-FUBINACA
Legal status
Legal status
Identifiers
  • N-(1-amino-3-phenyl-1-oxopropan-2-yl)-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC24H21FN4O2
Molar mass416.456 g·mol−1
3D model (JSmol)
  • O=C(N[C@H](C(N)=O)CC1=CC=CC=C1)C2=NN(CC3=CC=C(F)C=C3)C4=C2C=CC=C4
  • InChI=1S/C24H21FN4O2/c25-18-12-10-17(11-13-18)15-29-21-9-5-4-8-19(21)22(28-29)24(31)27-20(23(26)30)14-16-6-2-1-3-7-16/h1-13,20H,14-15H2,(H2,26,30)(H,27,31)/t20-/m0/s1
  • Key:TZXBEYFALIFOAG-FQEVSTJZSA-N

APP-FUBINACA is anindazole-basedsynthetic cannabinoid that has been sold online as adesigner drug.[1] Pharmacological testing showed APP-FUBINACA to have only moderate affinity for theCB1 receptor, with a Ki of 708 nM, while its EC50 was not tested.[2] It contains aphenylalanine amino acid residue in its structure.[3]

Legality

[edit]

Sweden's public health agency suggested to classify APP-FUBINACA as hazardous substance on March 24, 2015.[4]

See also

[edit]

References

[edit]
  1. ^"APP-FUBINACA". Cayman Chemical. Retrieved15 July 2015.
  2. ^WO 2009106982, Buchler IP, Hayes MJ, Hedge SG, Hockerman SL, Jones DL, Kortum SW, Rico JG, Tenbrink RE, Wu KK, "Indazole derivatives", published 3 September 2009, assigned to Pfizer Inc 
  3. ^Evelyn, Alex."HHC (Hexahydrocannabinol)". Retrieved19 December 2021.
  4. ^"Fler ämnen föreslås bli klassade som narkotika eller hälsofarlig vara". Folkhälsomyndigheten. Retrieved16 July 2015.
  5. ^Cannaert A, Sparkes E, Pike E, Luo JL, Fang A, Kevin RC, et al. (December 2020). "in Vitro Cannabinoid Receptor 1 Activity of Recently Detected Synthetic Cannabinoids 4F-MDMB-BICA, 5F-MPP-PICA, MMB-4en-PICA, CUMYL-CBMICA, ADB-BINACA, APP-BINACA, 4F-MDMB-BINACA, MDMB-4en-PINACA, A-CHMINACA, 5F-AB-P7AICA, 5F-MDMB-P7AICA, and 5F-AP7AICA".ACS Chemical Neuroscience.11 (24):4434–4446.doi:10.1021/acschemneuro.0c00644.PMID 33253529.S2CID 227246346.
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