 | |
| Names | |
|---|---|
| IUPAC name N,N′-Dibenzhydrylethane-1,2-diamine | |
| Identifiers | |
| |
3D model (JSmol) |
|
| ChemSpider | |
| |
| |
| Properties | |
| C28H28N2 | |
| Molar mass | 392.546 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
AMN082 (N,N′-dibenzhydrylethane-1,2-diamine) is a selectivemetabotropic glutamate receptor 7 (mGluR7)allostericagonist.[1][2] It mimics the effect ofglutamate. AMN082 is the first selective mGluR7agonist and has expanded the potential array of research opportunities on the effects of mGluR7 in the central nervous system.
The two main types ofglutamate receptors areionotropic receptors andmetabotropic receptors. Ionotropic receptors (iGluRs) are fast-actingligand-gated ion channels and includeAMPA receptors,kainate receptors, andNMDA receptors. Metabotropic receptors areG-protein coupled receptors that mediate slower, longer-lasting effects through second messenger systems and are responsible for other neuronal functions that are not typically controlled by iGluRs. mGluRs are split into 3 separate groups (Group I, Group II, Group III) based on pharmacological profile, sequence homology, and preferred signal transduction pathway. mGlur7 is a member of Group III, the least studied of the groups. AMN082 is pharmacological tool used to expand research on Group III mGluRs.
