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| Other names | AMG 133 |
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Maridebart cafraglutide (also known asMariTide;[1] developmental nameAMG 133) is an investigational drug developed byAmgen for the treatment ofobesity. It is an agonist of theGLP-1 receptor (GLP-1R) and an antagonist of theglucose-dependent insulinotropic polypeptide receptor (GIPR). Namely, MariTide consists of a monoclonal antibody against GIPR conjugated to two peptidic GLP-1R agonist molecules via amino acid linkers.[2] In a preliminary trial, AMG 133 resulted in a 14.5 percent weight loss after 12 weeks at the highest dose tested.[3][4][5]
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