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| Formula | C25H36O2S2 |
| Molar mass | 432.68 g·mol−1 |
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AMG-3 (part of theAM cannabinoid series) is ananalgesic drug which is acannabinoidagonist. It is a derivative of Δ8-THC substituted with adithiolane group on the 3-position side chain.[1] AMG-3 is a potent agonist at bothCB1 andCB2receptors with aKi of 0.32 nM at CB1 and 0.52 nM at CB2,[2][3] and its particularly high binding affinity has led to it being used as a template for further structural development of novel cannabinoid drugs.[4] It hassedative and analgesic effects, with analgesia lasting for up to 36 hours after administration.[5]
Media related toAMG-3 at Wikimedia Commons