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AMG-1

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
AMG-1
Identifiers
  • (6aR,10aR)-3-(Hept-1-ynyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC23H30O2
Molar mass338.491 g·mol−1
3D model (JSmol)
  • CC=3CC1c2c(O)cc(C#CCCCCC)cc2OC(C)(C)C1CC=3
  • InChI=1S/C23H30O2/c1-5-6-7-8-9-10-17-14-20(24)22-18-13-16(2)11-12-19(18)23(3,4)25-21(22)15-17/h11,14-15,18-19,24H,5-8,12-13H2,1-4H3/t18-,19-/m1/s1 checkY
  • Key:PYCLMAJRHLLHNO-RTBURBONSA-N checkY
 ☒NcheckY (what is this?)  (verify)

AMG-1 (part of theAM cannabinoid series) is ananalgesic drug which is acannabinoidagonist. It is a derivative ofΔ8-THC with a rigidified and extended 3-position side chain. AMG-1 is a potent agonist at bothCB1 andCB2 with moderate selectivity for CB1, with aKi of 0.6 nM at CB1 vs 3.1 nM at CB2.[1][2]

See also

[edit]

References

[edit]
  1. ^Papahatjis DP, Nikas SP, Kourouli T, Chari R, Xu W, Pertwee RG,Makriyannis A (July 2003). "Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'".Journal of Medicinal Chemistry.46 (15):3221–9.doi:10.1021/jm020558c.PMID 12852753.
  2. ^Keimowitz AR, Martin BR, Razdan RK, Crocker PJ, Mascarella SW, Thomas BF (January 2000). "QSAR analysis of Delta(8)-THC analogues: relationship of side-chain conformation to cannabinoid receptor affinity and pharmacological potency".Journal of Medicinal Chemistry.43 (1):59–70.doi:10.1021/jm9902281.PMID 10633038.
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