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| Formula | C27H40O4 |
| Molar mass | 428.613 g·mol−1 |
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AM-938 (part of theAM cannabinoid series) is ananalgesic drug which is acannabinoid receptor agonist. It is a derivative ofHU-210 which has been substituted with a 6β-(3-hydroxyprop-1-ynyl) group. This adds a "southern"aliphatichydroxyl group to the molecule as seen in theCP-series of nonclassical cannabinoid drugs, and so AM-938 represents a hybrid structure between theclassical andnonclassicalcannabinoid families,[1] with the 6-hydroxyalkyl chain rigidified with atriple bond. This gives AM-938 a greater degree of selectivity, so while it is still a potent agonist at bothCB1 andCB2, it is reasonably selective for CB2, with aKi of 0.3 nM at CB2 and 1.2 nM at CB1, a selectivity of around four-fold.[2][3]
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