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| Formula | C27H44O4 |
| Molar mass | 432.645 g·mol−1 |
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AM-919 (part of theAM cannabinoid series) is ananalgesic drug which is acannabinoid receptor agonist. It is a derivative ofHU-210 which has been substituted with a 6β-(3-hydroxypropyl) group. This adds a "southern"aliphatichydroxyl group to the molecule as seen in theCP-series of nonclassical cannabinoid drugs, and so AM-919 represents a hybrid structure between the classicaldibenzopyran and nonclassicalcannabinoid families.[1]
AM-919 is somewhat less potent than HU-210 itself, but is still a potent agonist at bothCB1 andCB2 with moderate selectivity for CB1, with aKi of 2.2 nM at CB1 and 3.4 nM at CB2.[2][3]
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