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AM-7438

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
AM-7438
Identifiers
  • 3-cyanopropyl 2-[(6aR,10aR)-1-hydroxy-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-3-yl]-2-methylpropanoate
CAS Number
PubChemCID
ChemSpider
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC24H31NO4
Molar mass397.515 g·mol−1
3D model (JSmol)
  • CC1=CC[C@@H]2[C@@H](C1)C3=C(C=C(C=C3OC2(C)C)C(C)(C)C(=O)OCCCC#N)O
  • InChI=1S/C24H31NO4/c1-15-8-9-18-17(12-15)21-19(26)13-16(14-20(21)29-24(18,4)5)23(2,3)22(27)28-11-7-6-10-25/h8,13-14,17-18,26H,6-7,9,11-12H2,1-5H3/t17-,18-/m1/s1
  • Key:PGSJGFYQNYPKOJ-QZTJIDSGSA-N

AM-7438 is a drug which is acannabinoid receptor agonist, developed by the research team led by DrAlexandros Makriyannis. It is a derivative of Δ8-THC which has been substituted with a side chain containing a metabolically labileester group, allowing the molecule to be rapidly metabolised to an inactive form, in a similar manner to drugs such asremifentanil,remimazolam andSN 35210. This means that while AM-7438 retains potent cannabinoid effects, it has a much shorter duration of action than most related compounds.[1]


References

[edit]
  1. ^Nikas SP, Sharma R, Paronis CA, Kulkarni S, Thakur GA, Hurst D, Wood JT, Gifford RS, Rajarshi G, Liu Y, Raghav JG, Guo JJ, Järbe TU, Reggio PH, Bergman J, Makriyannis A (January 2015)."Probing the carboxyester side chain in controlled deactivation (−)-δ(8)-tetrahydrocannabinols".Journal of Medicinal Chemistry.58 (2):665–81.doi:10.1021/jm501165d.PMC 4306527.PMID 25470070.
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