![]() | |
Legal status | |
---|---|
Legal status |
|
Identifiers | |
| |
CAS Number | |
PubChemCID | |
ChemSpider |
|
UNII | |
ChEBI | |
CompTox Dashboard(EPA) | |
Chemical and physical data | |
Formula | C20H19FINO |
Molar mass | 435.281 g·mol−1 |
3D model (JSmol) | |
| |
| |
![]() ![]() |
AM-694 (1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole) is adesigner drug that acts as a potent and selectiveagonist for thecannabinoid receptorCB1. It is used in scientific research for mapping the distribution of CB1 receptors.[1]
AM-694 is anagonist forcannabinoid receptors. It has aKi of 0.08 nM atCB1 and 18 times selectivity overCB2 with aKi of 1.44 nM.[2] It is unclear what is responsible for this unusually high CB1 binding affinity, but it makes the18Fradiolabelled derivative of AM-694 useful for mapping the distribution of CB1 receptors in the body.[1]
Pathways ofmetabolism includehydrolytic defluorination,carboxylation, andmonohydroxylation of theN-alkyl chain.[3][4]