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| ECHA InfoCard | 100.229.964 |
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| Formula | C23H25IN2O3 |
| Molar mass | 504.368 g·mol−1 |
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AM-630 (6-Iodopravadoline) is a drug that acts as a potent and selectiveinverse agonist for thecannabinoid receptorCB2, with aKi of 32.1 nM at CB2 and 165x selectivity overCB1, at which it acted as a weakpartial agonist.[1][2] It is used in the study of CB2 mediated responses and has been used to investigate the possible role of CB2 receptors in the brain.[3][4] AM-630 is significant as one of the first indole derived cannabinoid ligands substituted on the 6-position of the indole ring, a position that has subsequently been found to be important in determining affinity and efficacy at both the CB1 and CB2 receptors, and has led to the development of many related derivatives.[5][6][7][8][9]
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