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| Formula | C26H34N2O |
| Molar mass | 390.571 g·mol−1 |
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AM-1248 is a drug that acts as a moderately potentagonist for both thecannabinoid receptorsCB1 andCB2, but with some dispute between sources over its exact potency and selectivity. Replacing the 3-(1-naphthoyl) group found in many indole derived cannabinoid ligands, with anadamantoyl group, generally confers significant CB2 selectivity,[1] but reasonable CB1 affinity and selectivity is retained when an N-methylpiperidin-2-ylmethyl substitution is used at the indole 1-position.[2][3] The related compound1-pentyl-3-(1-adamantoyl)indole was identified as having been sold as acannabinoiddesigner drug in Hungary in 2011, along with another synthetic cannabinoidAM-679.[4]
Sweden's public health agency suggested to classify AM-1248 as hazardous substance on June 1, 2015.[5]
As of October 2015 AM-1248 is a controlled substance in China.[6]
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