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| Formula | C27H27N3O3 |
| Molar mass | 441.531 g·mol−1 |
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AM-1221 is a drug that acts as a potent and selectiveagonist for thecannabinoid receptorCB2, with aKi of 0.28 nM at CB2 and 52.3 nM at theCB1 receptor, giving it around 180 times selectivity for CB2.[1] The 2-methyl and 6-nitro groups on theindole ring both tend to increase CB2 affinity while generally reducing affinity at CB1, explaining the high CB2 selectivity of AM-1221. However, despite this relatively high selectivity for CB2, its CB1 affinity is still too strong to make it useful as a truly selective CB2 agonist, so the related compoundAM-1241 is generally preferred for research purposes.[2][3]
In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as AM-1221 areSchedule I Controlled Substances.[4]
It is illegal to supply, trade, sell, distribute, import or transport the pharmaceutical drug in the UK under thePsychoactive Substances Act 2016 which was in force on May 26, 2016.
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