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AM-087

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
AM-087
Identifiers
  • (6aR,10aR)-3-(2-Methyl-6-bromohex-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC23H33BrO2
Molar mass421.419 g·mol−1
3D model (JSmol)
  • CC3(C)C1CC=C(C)CC1c2c(O)cc(C(C)(C)CCCCBr)cc2O3
  • InChI=1S/C23H33BrO2/c1-15-8-9-18-17(12-15)21-19(25)13-16(14-20(21)26-23(18,4)5)22(2,3)10-6-7-11-24/h8,13-14,17-18,25H,6-7,9-12H2,1-5H3/t17-,18-/m1/s1 checkY
  • Key:RJPGJHLVEUSRRA-QZTJIDSGSA-N checkY
  (verify)

AM-087 (part of theAM cannabinoid series) is ananalgesic drug which acts as acannabinoidagonist.[1] It is a derivative of Δ8-THC, substituted on the 3-position side chain. AM-087 is a potentCB1 agonist with aKi of 0.43 nM, making it around 100 times more potent thanTHC itself. This is most likely due to the bulkybromine substituent on the side chain.[2]

See also

[edit]

References

[edit]
  1. ^Martin BR, Compton DR, Semus SF, Lin S, Marciniak G, Grzybowska J, et al. (October 1993). "Pharmacological evaluation of iodo and nitro analogs of Δ8-THC and Δ9-THC".Pharmacology, Biochemistry, and Behavior.46 (2):295–301.doi:10.1016/0091-3057(93)90356-X.PMID 8265683.S2CID 140209578.
  2. ^Charalambous A, Lin S, Marciniak G, Banijamali A, Friend FL, Compton DR, et al. (November 1991). "Pharmacological evaluation of halogenated delta 8-THC analogs".Pharmacology, Biochemistry, and Behavior.40 (3):509–12.doi:10.1016/0091-3057(91)90355-6.PMID 1666915.S2CID 140209927.
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