AM-087

Identifiers
IUPAC name (6aR,10aR)-3-(2-Methyl-6-bromohex-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
CAS Number	152674-96-9 Y
PubChemCID	10717065
ChemSpider	8892405 Y
UNII	B4C266FTR4
ChEMBL	ChEMBL199561 Y
CompTox Dashboard(EPA)	DTXSID301027466
Chemical and physical data
Formula	C23H33BrO2
Molar mass	421.419 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC3(C)C1CC=C(C)CC1c2c(O)cc(C(C)(C)CCCCBr)cc2O3
InChI InChI=1S/C23H33BrO2/c1-15-8-9-18-17(12-15)21-19(25)13-16(14-20(21)26-23(18,4)5)22(2,3)10-6-7-11-24/h8,13-14,17-18,25H,6-7,9-12H2,1-5H3/t17-,18-/m1/s1 Y Key:RJPGJHLVEUSRRA-QZTJIDSGSA-N Y
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AM-087 (part of theAM cannabinoid series) is ananalgesic drug which acts as acannabinoidagonist.^[1] It is a derivative of Δ8-THC, substituted on the 3-position side chain. AM-087 is a potentCB₁ agonist with aKi of 0.43 nM, making it around 100 times more potent thanTHC itself. This is most likely due to the bulkybromine substituent on the side chain.^[2]

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