The protein encoded by this gene is a member of theAKT subfamily ofserine/threonine protein kinases. AKT kinases are known to be regulators of cell signaling in response toinsulin andgrowth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation,apoptosis,tumorigenesis, as well asglycogen synthesis andglucose uptake. This kinase has been shown to be stimulated byplatelet-derived growth factor (PDGF), insulin, andinsulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.[7] Mice lacking Akt3 have a normal glucose metabolism (no diabetes), have approximately normal body weight, but have a 25% reduction in brain mass. Incidentally, Akt3 is highly expressed in the brain.
^Hodgkinson CP, Sale EM, Sale GJ (2002). "Characterization of PDK2 activity against protein kinase B gamma".Biochemistry.41 (32):10351–9.doi:10.1021/bi026065r.PMID12162751.
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Kapasi AA, Fan S, Singhal PC (2001). "Role of 14-3-3epsilon, c-Myc/Max, and Akt phosphorylation in HIV-1 gp 120-induced mesangial cell proliferation".Am. J. Physiol. Renal Physiol.280 (2): F333–42.doi:10.1152/ajprenal.2001.280.2.F333.PMID11208609.S2CID29992656.
Zinda MJ, Johnson MA, Paul JD, Horn C, Konicek BW, Lu ZH, Sandusky G, Thomas JE, Neubauer BL, Lai MT, Graff JR (2001). "AKT-1, -2, and -3 are expressed in both normal and tumor tissues of the lung, breast, prostate, and colon".Clin. Cancer Res.7 (8):2475–9.PMID11489829.
Hodgkinson CP, Sale EM, Sale GJ (2002). "Characterization of PDK2 activity against protein kinase B gamma".Biochemistry.41 (32):10351–9.doi:10.1021/bi026065r.PMID12162751.
