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| Routes of administration | Oral[1] |
| Drug class | Selectiveα2B-adrenergic receptorantagonist;Analgesic |
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| Formula | C12H12FNOS |
| Molar mass | 237.29 g·mol−1 |
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ADRIANA is aselectiveα2B-adrenergic receptorantagonist.[1] It is described as highly selective over theα2A- andα2C-adrenergic receptors.[1] The drug stimulatesnorepinephrine release in the spinaldorsal horn and haspotentanalgesic effects in rodents and non-human primates.[1] It isorally active.[1] ADRIANA was first described in thescientific literature by Masayasu Toyomoto and colleagues in 2025.[1] It is said to be the first selective α2B-adrenergic receptor antagonist to have been developed.[1]
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