ADBICA

Clinical data
ATC code	racemate: none
Legal status
Legal status	CA: Schedule II DE: NpSG (Industrial and scientific use only) UK: Class B
Identifiers
IUPAC name N-(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-pentyl-1H-indole-3-carboxamide
CAS Number	racemate: 1445583-48-1 Y
PubChemCID	racemate: 72710773
ChemSpider	racemate: 29342130
UNII	racemate: Q71G788A6H S isomer: P0248QCZ04 Y
CompTox Dashboard(EPA)	racemate: DTXSID801009996
Chemical and physical data
Formula	C20H29N3O2
Molar mass	343.471 g·mol−1
3D model (JSmol)	racemate: Interactive image S isomer: Interactive image
SMILES racemate: CCCCCN1C=C(C2=CC=CC=C21)C(=O)NC(C(=O)N)C(C)(C)C S isomer: CCCCCN1C=C(C2=CC=CC=C21)C(=O)N[C@H](C(=O)N)C(C)(C)C
InChI racemate: InChI=1S/C20H29N3O2/c1-5-6-9-12-23-13-15(14-10-7-8-11-16(14)23)19(25)22-17(18(21)24)20(2,3)4/h7-8,10-11,13,17H,5-6,9,12H2,1-4H3,(H2,21,24)(H,22,25) Key:IXUYMXAKKYWKRG-UHFFFAOYSA-N

ADBICA (also known asADB-PICA) is adesigner drug identified insynthetic cannabis blends in Japan in 2013.^[1] ADBICA had not previously been reported in the scientific literature prior to its sale as a component of synthetic cannabis blends. ADBICA features a carboxamide group at the 3-indole position, likeSDB-001 andSTS-135. The stereochemistry of the tert-butyl side-chain in the product is unresolved, though in a large series of indazole derivatives structurally similar to ADBICA that are disclosed in Pfizer patent WO 2009/106980, activity resides exclusively in the (S) enantiomers.^[2] ADBICA is a potentagonist of theCB₁ receptor andCB₂ receptor with an EC₅₀ value of 0.69 nM and 1.8 nM respectively.^[3]

As of October 2015 ADBICA is a controlled substance in China.^[4]

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