Theactivin A receptor also known asACVR1C orALK-7 is a protein that in humans is encoded by the ACVR1Cgene.[5] ACVR1C is a type I receptor for theTGFB family of signaling molecules.[5]
ACVR1C transduces signals ofNodal.Nodal binds toACVR2B and then forms a complex with ACVR1C. These go on to recruit theR-SMADsSMAD2 orSMAD3.[6]
Upon ligand binding, type I receptorsphosphorylate cytoplasmicSMAD familytranscription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.[5]
