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ACER3

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

ACER3

Identifiers

Aliases

ACER3, APHC, PHCA, alkaline ceramidase 3, PLDECO

External IDs

OMIM:617036;MGI:1913440;HomoloGene:5410;GeneCards:ACER3;OMA:ACER3 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q13.5	Start	76,860,859bp^[1]
Band	11q13.5	End	77,026,797bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 E1	Start	98,206,389bp^[2]
Band	7\|7 E1	End	98,321,208bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

endothelial cell

inferior ganglion of vagus nerve

mucosa of ileum

corpus callosum

pancreatic epithelial cell

pars reticulata

pars compacta

Brodmann area 46

subthalamic nucleus

buccal mucosa cell

Top expressed in

conjunctival fornix

cornea

interventricular septum

hair follicle

skin of external ear

sciatic nerve

decidua

skin of back

lobe of prostate

skin of abdomen

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity phytoceramidase activity N-acylsphingosine amidohydrolase activity dihydroceramidase activity ceramidase activity calcium ion binding zinc ion binding metal ion binding
Cellular component	integral component of membrane integral component of Golgi membrane integral component of endoplasmic reticulum membrane Golgi membrane Golgi apparatus endoplasmic reticulum membrane endoplasmic reticulum membrane
Biological process	sphingosine biosynthetic process sphingolipid biosynthetic process phytosphingosine biosynthetic process ceramide metabolic process positive regulation of cell population proliferation inflammatory response myelination regulation of programmed cell death ceramide catabolic process lipid metabolism sphingolipid metabolic process
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


55331


66190

Ensembl


ENSG00000078124


ENSMUSG00000030760

UniProt


Q9NUN7


Q9D099

RefSeq (mRNA)


NM_001300953 NM_001300954 NM_001300955 NM_018367


NM_025408

RefSeq (protein)


NP_001287882 NP_001287883 NP_001287884 NP_060837


NP_079684 NP_001347544 NP_001347545 NP_001347546

Location (UCSC)

Chr 11: 76.86 – 77.03 Mb

Chr 7: 98.21 – 98.32 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Alkaline ceramidase 3 also known asACER3 is aceramidase enzyme which inhumans is encoded by theACER3gene.^[5]^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000078124 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000030760 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mao C, Xu R, Szulc ZM, Bielawska A, Galadari SH, Obeid LM (July 2001)."Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide".J. Biol. Chem.276 (28):26577–88.doi:10.1074/jbc.M102818200.PMID 11356846.
^Mao C, Obeid LM (September 2008)."Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate".Biochim. Biophys. Acta.1781 (9):424–34.doi:10.1016/j.bbalip.2008.06.002.PMC 2614331.PMID 18619555.

External links

[edit]

HumanACER3 genome location andACER3 gene details page in theUCSC Genome Browser.

Strausberg RL, Feingold EA, Grouse LH, et al. (2002)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–5.doi:10.1038/ng1285.PMID 14702039.
Wheeler HE, Metter EJ, Tanaka T, et al. (2009). Gibson G (ed.)."Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging".PLOS Genet.5 (10): e1000685.doi:10.1371/journal.pgen.1000685.PMC 2752811.PMID 19834535.

Metabolism,lipid metabolism,glycolipid enzymes

Sphingolipid

Toglycosphingolipid	Glycosyltransferase Sulfotransferase
Toceramide	Fromganglioside Beta-galactosidase Hexosaminidase A Neuraminidase Glucocerebrosidase Fromgloboside Hexosaminidase B Alpha-galactosidase Beta-galactosidase Glucocerebrosidase Fromsphingomyelin Sphingomyelin phosphodiesterase Sphingomyelin phosphodiesterase 1 Fromsulfatide Arylsulfatase A Galactosylceramidase
Tosphingosine	Ceramidase ACER1 ACER2 ACER3 ASAH1 ASAH2 ASAH2B ASAH2C
Other	Sphingosine kinase

NCL

Ceramide synthesis

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