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ACER2

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From Wikipedia, the free encyclopedia

Ceramidase enzyme

ACER2

Identifiers

Aliases

ACER2, ALKCDase, ASAH3L, alkalina ceramidasa, ALKCDase2, alkaline ceramidase 2

External IDs

OMIM:613492;MGI:1920932;HomoloGene:14986;GeneCards:ACER2;OMA:ACER2 - orthologs

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9p22.1	Start	19,409,009bp^[1]
Band	9p22.1	End	19,452,505bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4\|4 C4	Start	86,792,633bp^[2]
Band	4\|4 C4	End	86,853,059bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

urinary bladder

gonad

placenta

subcutaneous adipose tissue

stomach

testicle

body of stomach

duodenum

body of pancreas

islet of Langerhans

Top expressed in

transitional epithelium of urinary bladder

right lung

right lung lobe

left lung

embryo

tail of embryo

genital tubercle

gastrula

atrium

left lung lobe

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	dihydroceramidase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity N-acylsphingosine amidohydrolase activity ceramidase activity metal ion binding
Cellular component	integral component of membrane integral component of Golgi membrane Golgi apparatus membrane Golgi membrane
Biological process	positive regulation of cell death response to retinoic acid ceramide metabolic process lipid metabolism sphingosine biosynthetic process sphingolipid biosynthetic process negative regulation of cell-matrix adhesion positive regulation of cell population proliferation activation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of cell adhesion mediated by integrin cellular response to DNA damage stimulus regulation of autophagy DNA damage response, signal transduction by p53 class mediator regulation of apoptotic process ceramide catabolic process sphingolipid metabolic process
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


340485


230379

Ensembl


ENSG00000177076


ENSMUSG00000038007

UniProt


Q5QJU3


Q8VD53

RefSeq (mRNA)


NM_001010887


NM_001290541 NM_001290543 NM_139306 NM_028605

RefSeq (protein)


NP_001010887


NP_001277470 NP_001277472 NP_647467

Location (UCSC)

Chr 9: 19.41 – 19.45 Mb

Chr 4: 86.79 – 86.85 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Alkaline ceramidase 2 also known asACER2 is aceramidase enzyme which in humans is encoded by the ACER2gene.^[5]

Function

[edit]

The ACER2/sphingosine pathway plays an important role in regulating integrin β1 subunit (ITGB1) maturation andcell adhesion mediated by β1 integrins.^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000177076 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000038007 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mao C, Obeid LM (September 2008)."Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate".Biochim. Biophys. Acta.1781 (9):424–34.doi:10.1016/j.bbalip.2008.06.002.PMC 2614331.PMID 18619555.
^Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM, Mao C (February 2009)."Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion".FASEB J.23 (2):656–66.doi:10.1096/fj.08-115634.PMC 2630785.PMID 18945876.

External links

[edit]

HumanACER2 genome location andACER2 gene details page in theUCSC Genome Browser.

Xu R, Jin J, Hu W, et al. (2006)."Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P".FASEB J.20 (11):1813–25.doi:10.1096/fj.05-5689com.PMID 16940153.S2CID 20973940.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Humphray SJ, Oliver K, Hunt AR, et al. (2004)."DNA sequence and analysis of human chromosome 9".Nature.429 (6990):369–74.Bibcode:2004Natur.429..369H.doi:10.1038/nature02465.PMC 2734081.PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004)."Large-scale cDNA transfection screening for genes related to cancer development and progression".Proc. Natl. Acad. Sci. U.S.A.101 (44):15724–9.Bibcode:2004PNAS..10115724W.doi:10.1073/pnas.0404089101.PMC 524842.PMID 15498874.

Metabolism,lipid metabolism,glycolipid enzymes

Sphingolipid

Toglycosphingolipid	Glycosyltransferase Sulfotransferase
Toceramide	Fromganglioside Beta-galactosidase Hexosaminidase A Neuraminidase Glucocerebrosidase Fromgloboside Hexosaminidase B Alpha-galactosidase Beta-galactosidase Glucocerebrosidase Fromsphingomyelin Sphingomyelin phosphodiesterase Sphingomyelin phosphodiesterase 1 Fromsulfatide Arylsulfatase A Galactosylceramidase
Tosphingosine	Ceramidase ACER1 ACER2 ACER3 ASAH1 ASAH2 ASAH2B ASAH2C
Other	Sphingosine kinase

NCL

Ceramide synthesis

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