AC-90179 is apiperidine derivative which acts as aninverse agonist at the5-HT2Aserotoninreceptor and an antagonist at5-HT2C. It was developed as a potential antipsychotic but was not pursued for medical applications due to poor oral bioavailability; however, it continues to be used as a tool compound in pharmacological research.[1][2]
^Weiner DM, Burstein ES, Nash N, Croston GE, Currier EA, Vanover KE, Harvey SC, Donohue E, Hansen HC, Andersson CM, Spalding TA, Gibson DF, Krebs-Thomson K, Powell SB, Geyer MA, Hacksell U, Brann MR (October 2001). "5-hydroxytryptamine2A receptor inverse agonists as antipsychotics".The Journal of Pharmacology and Experimental Therapeutics.299 (1):268–76.doi:10.1016/S0022-3565(24)29327-7.PMID11561089.
^Vanover KE, Harvey SC, Son T, Bradley SR, Kold H, Makhay M, Veinbergs I, Spalding TA, Weiner DM, Andersson CM, Tolf BR, Brann MR, Hacksell U, Davis RE (September 2004). "Pharmacological characterization of AC-90179 [2-(4-methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide hydrochloride]: a selective serotonin 2A receptor inverse agonist".The Journal of Pharmacology and Experimental Therapeutics.310 (3):943–51.doi:10.1124/jpet.104.066688.PMID15102927.S2CID12205122.
