Protein-coding gene in the species Homo sapiens
alpha/beta-Hydrolase domain containing 6 (ABHD6 ), also known asmonoacylglycerol lipase ABHD6 or2-arachidonoylglycerol hydrolase is an enzyme that in humans is encoded by the ABHD6gene .
ABHD6 is a serine hydrolyzing enzyme that possesses typicalα/β-hydrolase family domains. ABHD6 was first studied because of its over-expression in certain forms oftumours .[ 5]
ABHD6 has been linked to regulation of theendocannabinoid system as it controls the accumulation of2-arachidonoylglycerol (2-AG) at thecannabinoid receptors .[ 6]
ABHD6 accounts for about 4% of 2-AG brainhydrolysis .[ 7] monoacylglycerol lipase (MAGL),ABHD12 , and ABHD6 control about 99% of 2-AG signalling in the brain,[ 7] [ 8] subcellular distribution, suggesting that they regulate distinct pools of 2-AG in thenervous system .[ 9]
^a b c GRCh38: Ensembl release 89: ENSG00000163686 –Ensembl , May 2017^a b c GRCm38: Ensembl release 89: ENSMUSG00000025277 –Ensembl , May 2017^ "Human PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ Li F, Fei X, Xu J, Ji C (April 2009). "An unannotated alpha/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines".Molecular Biology Reports .36 (4):691– 6.doi :10.1007/s11033-008-9230-7 .PMID 18360779 .S2CID 6795598 . ^ Marrs WR, Blankman JL, Horne EA, Thomazeau A, Lin YH, Coy J, Bodor AL, Muccioli GG, Hu SS, Woodruff G, Fung S, Lafourcade M, Alexander JP, Long JZ, Li W, Xu C, Möller T, Mackie K, Manzoni OJ, Cravatt BF, Stella N (August 2010)."The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors" .Nature Neuroscience .13 (8):951– 7.doi :10.1038/nn.2601 .PMC 2970523 PMID 20657592 . ^a b Cannabinoid Receptors—Advances in Research and Application: 2012 Edition: ScholarlyBrief ISBN 978-1-4816-0672-1 ^ Savinainen JR, Saario SM, Laitinen JT (February 2012)."The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors" .Acta Physiologica .204 (2):267– 76.doi :10.1111/j.1748-1716.2011.02280.x .PMC 3320662 PMID 21418147 . ^ Blankman JL, Simon GM, Cravatt BF (December 2007)."A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol" .Chemistry & Biology .14 (12):1347– 56.doi :10.1016/j.chembiol.2007.11.006 .PMC 2692834 PMID 18096503 .
Receptor (ligands )
CB1 Tooltip Cannabinoid receptor type 1
Agonists(abridged,full list ) Inverse agonists Antagonists
CB2 Tooltip Cannabinoid receptor type 2
Agonists 2-AG 2-AGE (noladin ether) 3,3'-Diindolylmethane 4-O-Methylhonokiol α-Amyrin · β-Amyrin A-796,260 A-834,735 A-836,339 AM-1172 AM-1221 AM-1235 AM-1241 AM-2232 Anandamide AZ-11713908 Cannabinol Caryophyllene CB-13 CBS-0550 CP 55,940 GW-405,833 (L-768,242) GW-842,166X HU-308 JTE 7-31 JWH-007 JWH-015 JWH-018 JWH-73 JWH-133 L-759,633 L-759,656 Lenabasum (anabasum) Magnolol MDA-19 Nabitan NADA Olorinab (APD-371) PF-03550096 S-444,823 SER-601 Serinolamide A UR-144 Tedalinab THC (dronabinol) THCV Tetrahydromagnolol Virodhamine Antagonists
NAGly GPR18)
GPR55
GPR119
Transporter (modulators )
eCBTs Tooltip Endocannabinoid transporter
Enzyme (modulators)
Others Others: 2-PG (directly potentiates activity of 2-AG at CB1 receptor) ARN-272 (FAAH-like anandamide transporter inhibitor)
