Multidrug resistance-associated protein 7 is aprotein that in humans is encoded by theABCC10gene.[5][6]
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- andintra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.[6]
Hopper E, Belinsky MG, Zeng H, et al. (2001). "Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily".Cancer Lett.162 (2):181–91.doi:10.1016/S0304-3835(00)00646-7.PMID11146224.
Chen ZS, Hopper-Borge E, Belinsky MG, et al. (2003). "Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10)".Mol. Pharmacol.63 (2):351–8.doi:10.1124/mol.63.2.351.PMID12527806.S2CID26642179.
Kao HH, Chang MS, Cheng JF, Huang JD (2003). "Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7".J. Biomed. Sci.10 (1):98–110.doi:10.1159/000068078.PMID12566991.S2CID202649323.
Naramoto H, Uematsu T, Uchihashi T, et al. (2007). "Multidrug resistance-associated protein 7 expression is involved in cross-resistance to docetaxel in salivary gland adenocarcinoma cell lines".Int. J. Oncol.30 (2):393–401.doi:10.3892/ijo.30.2.393 (inactive 11 July 2025).PMID17203221.{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link)
