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| Formula | C23H32N2O |
| Molar mass | 352.522 g·mol−1 |
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AB-005 or[1-[(1-methylpiperidin-2-yl)methyl]-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)-methanone is adesigner drug offered by online vendors as a cannabimimetic agent. The structure and pharmacological activity of AB-005 was published in 2010, prior to its commercial availability in 2012, where it was reported to have high affinity for both CB1 (Ki = 5.5 nM) and CB2 receptors (Ki = 0.48 nM).[1] AB-005 features groups found in other previously reported synthetic cannabinoids: the tetramethylcyclopropane group ofUR-144 andXLR-11 as well as the (1-methyl-2-piperidinyl)methyl substituent ofAM-1248 andAM-1220. No information regarding the in vivo activity of AB-005 has been published, and only anecdotal reports are known of its psychoactivity in humans.
In 2013, psychoactive products in New Zealand containing this drug were given interim approval under psychoactive substances legislation.[2]
