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9-Nor-9β-hydroxyhexahydrocannabinol

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
9-Nor-9β-hydroxyhexahydrocannabinol
Identifiers
  • 6,6-Dimethyl-3-pentyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromene-1,9-diol
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC20H30O3
Molar mass318.457 g·mol−1
3D model (JSmol)
  • CCCCCc1cc(c2c(c1)OC([C@H]3[C@H]2C[C@@H](CC3)O)(C)C)O
  • InChI=1S/C20H30O3/c1-4-5-6-7-13-10-17(22)19-15-12-14(21)8-9-16(15)20(2,3)23-18(19)11-13/h10-11,14-16,21-22H,4-9,12H2,1-3H3/t14-,15-,16-/m1/s1
  • Key:AAIHVZNCFQTVCA-BZUAXINKSA-N

9-Nor-9β-hydroxyhexahydrocannabinol (9-nor-9beta-HHC; sometimes incorrectly confused with 11-nor-9β-hydroxyhexahydrocannabinol[1]) is acannabinoid first discovered from early modifications to the structure ofTHC, in a search for the simplest compound that could still fulfill the binding requirements to produce cannabis-like activity.[2][3]

11-Hydroxyhexahydrocannabinol is the structurally related methylene homologue of 11-nor-9β-hydroxyhexahydrocannabinol that has been found as a minor active metabolite oftetrahydrocannabinol, and also a metabolite of the trace cannabinoidhexahydrocannabinol.[4]

See also

[edit]

References

[edit]
  1. ^"9-Hydroxy-9-norhexahydrocannabinol".
  2. ^Johnson MR, Althuis TH, Bindra JS, Harbert CA, Melvin LS, Milne GM (1980).Potent Analgetics Derived From 9-Nor-9β-Hydroxyhexahydrocannabinol. NIDA Research Monograph. Vol. 34. pp. 68−74.
  3. ^Melvin LS, Johnson MR (1987)."Relationships of Tricyclic and Nonclassical Bicyclic Cannabinoids". In Rapaka RS, Makriyannis A (eds.).Structure-activity Relationships of the Cannabinoids. NIDA Research Monograph. Vol. 79. pp. 31–47.
  4. ^Järbe TU, Hiltunen AJ, Lander N, Mechoulam R (August 1986). "Cannabimimetic activity (delta 1-THC cue) of cannabidiol monomethyl ether and two stereoisomeric hexahydrocannabinols in rats and pigeons".Pharmacology, Biochemistry, and Behavior.25 (2):393–9.doi:10.1016/0091-3057(86)90015-8.PMID 3020594.S2CID 28373651.
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