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8-OH-PBZI

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Chemical compound

Pharmaceutical compound

8-OH-PBZI
Clinical data

ATC code	none
Identifiers
IUPAC name (3aS,9bR)-3-propyl-1,2,3a,4,5,9b-hexahydrobenzo[e]indol-8-ol
CAS Number	251327-33-0^Y
PubChemCID	10353845
ChemSpider	8529297^Y
UNII	B8GYQ9JV5F
CompTox Dashboard(EPA)	DTXSID501028808
Chemical and physical data
Formula	C₁₅H₂₁NO
Molar mass	231.339 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCCN1CC[C@H]2[C@@H]1CCC3=C2C=C(C=C3)O
InChI InChI=1S/C15H21NO/c1-2-8-16-9-7-13-14-10-12(17)5-3-11(14)4-6-15(13)16/h3,5,10,13,15,17H,2,4,6-9H2,1H3/t13-,15+/m1/s1^Y Key:LJDRQPOQHHOXHM-HIFRSBDPSA-N^Y
(verify)

8-OH-PBZI is a drug used in scientific research which acts as a potent and selectiveagonist for thedopamine D₃ receptor.^[1]^[2]^[3]

^Scheideler MA, Martin J, Hohlweg R, Rasmussen JS, Naerum L, Ludvigsen TS, et al. (November 1997). "The preferential dopamine D3 receptor agonist cis-8-OH-PBZI induces limbic Fos expression in rat brain".European Journal of Pharmacology.339 (2–3):261–70.doi:10.1016/S0014-2999(97)01372-1.PMID 9473144.
^Fink-Jensen A, Nielsen EB, Hansen L, Scheideler MA (January 1998). "Behavioral and neurochemical effects of the preferential dopamine D3 receptor agonist cis-8-OH-PBZI".European Journal of Pharmacology.342 (2–3):153–61.doi:10.1016/S0014-2999(97)01494-5.PMID 9548380.
^Malik P, Andersen MB, Peacock L (August 2004). "The effects of dopamine D3 agonists and antagonists in a nonhuman primate model of tardive dyskinesia".Pharmacology, Biochemistry, and Behavior.78 (4):805–10.doi:10.1016/j.pbb.2004.05.019.PMID 15301939.S2CID 19410897.

Agonists	Benzazepines:6-Br-APB Fenoldopam SKF-38,393 SKF-77,434 SKF-81,297 SKF-82,958 SKF-83,959 Trepipam Zelandopam Ergolines:Cabergoline CY-208,243 Dihydroergocryptine LEK-8829 Lisuride Pergolide Terguride Dihydrexidine derivatives:A-77636 A-86929 Adrogolide (ABT-431, DAS-431) Dihydrexidine Dinapsoline Dinoxyline Doxanthrine Phenethylamines:BCO-001 Deoxyepinephrine (N-methyldopamine, epinine) Dopexamine Etilevodopa Ibopamine L-DOPA (levodopa) Melevodopa L-Phenylalanine L-Tyrosine XP21279 Others:A-68930 Apomorphine Isocorypalmine Nuciferine PF-6649751 PF 6669571 Propylnorapomorphine Rotigotine SKF-89,145 SKF-89,626 Stepholidine Tavapadon Tetrahydropalmatine
PAMs	Tetrahydroisoquinolines:DETQ DPTQ Mevidalen
Antagonists	Typical antipsychotics:Butaclamol Chlorpromazine Chlorprothixene Flupentixol (flupenthixol) (+melitracen) Fluphenazine Loxapine Perphenazine (+amitriptyline) Pifluthixol Thioridazine Thiothixene Trifluoperazine (+tranylcypromine) Zuclopenthixol Atypical antipsychotics:Asenapine Clorotepine Clotiapine Clozapine DHA-clozapine Fluperlapine Iloperidone Norclozapine Norquetiapine Olanzapine (+fluoxetine) Paliperidone Quetiapine Risperidone Tefludazine Zicronapine Ziprasidone Zotepine Others:Berupipam Ecopipam EEDQ Metitepine (methiothepin) Odapipam Perlapine SCH-23390

Agonists

Antagonists

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