8,11-Dihydroxytetrahydrocannabinol

Identifiers
IUPAC name (6aR,8R,10aR)-9-(Hydroxymethyl)-6,6-dimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromene-1,8-diol
CAS Number	36913-21-0 N[EPA]
PubChemCID	101993955
ChemSpider	130500
CompTox Dashboard(EPA)	DTXSID80190397
Chemical and physical data
Formula	C21H30O4
Molar mass	346.467 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCCc1cc2OC(C)(C)[C@@H]3C[C@@H](O)C(=C[C@H]3c2c(O)c1)CO
InChI InChI=1S/C21H30O4/c1-4-5-6-7-13-8-18(24)20-15-10-14(12-22)17(23)11-16(15)21(2,3)25-19(20)9-13/h8-10,15-17,22-24H,4-7,11-12H2,1-3H3/t15-,16-,17-/m1/s1 Key:XTDYIISRNODHHT-BRWVUGGUSA-N

8,11-Dihydroxytetrahydrocannabinol (8β,11-diOH-Δ⁹-THC) is anactive metabolite ofTHC, the main active component ofcannabis. The 8β enantiomer retains psychoactive effects in animal studies with only slightly lower potency than THC, while the 8α enantiomer is much weaker. Both enantiomers have a shorter half-life in the body than11-hydroxy-THC, making 8,11-dihydroxy-THC potentially useful fordrug testing to distinguish between recent cannabis use and use longer in the past.^[1][2][3]

• 3'-Hydroxy-THC
• 7-Hydroxycannabidiol
• 11-Hydroxy-Delta-8-THC
• 11-Nor-9-carboxy-THC
• Cannabitriol
• Cannabiripsol

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