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| Names | |
|---|---|
| Preferred IUPAC name 7-Nitro-1H-indazole | |
| Identifiers | |
3D model (JSmol) | |
| ChEBI | |
| ChEMBL | |
| ChemSpider |
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| ECHA InfoCard | 100.019.032 |
| UNII | |
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| Properties | |
| C7H5N3O2 | |
| Molar mass | 163.1335 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
7-Nitroindazole, or7-NI, is aheterocyclicsmall molecule containing anindazole ring that has beennitrated at the 7 position. Nitroindazole acts as a selective inhibitor forneuronalnitric oxide synthase, a hemoproteinenzyme that, inneuronal tissue, convertsarginine tocitrulline andnitric oxide (NO).[1] Nitric oxide can diffuse through the plasma membrane into neighbouring cells, allowingcell signalling, so nitroindazole indirectly inhibits this signalling process.[2][3][4] Other inhibitors exist such as 3-bromo-7-nitroindazole, which is more potent but less specific,[5] orN-propyl-L-arginine (NPA), which acts on a different site.[6]
7-Nitroindazole is under investigation as a possible protective agent againstnerve damage caused byexcitotoxicity orneurodegenerative diseases.[1][7] It may act by reducingoxidative stress or by decreasing the amount ofperoxynitrite formed in these tissues. These effects are related to the inhibition of type 1 nitric oxide synthase. However, anticonvulsive effect is derived from some other mechanisms.[8]
