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7,N,N-TMT

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
7,N,N-TMT
Clinical data
Other names7,N,N-Trimethyltryptamine; 7-Methyl-DMT; 7-Me-DMT
Drug classSerotonergic psychedelic;Hallucinogen
Identifiers
  • 2-(7-methyl-1H-indol-3-yl)-N,N-dimethylethanamine
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC13H18N2
Molar mass202.301 g·mol−1
3D model (JSmol)
  • CC1=C(NC=C2CCN(C)C)C2=CC=C1
  • InChI=1S/C13H18N2/c1-10-5-4-6-12-11(7-8-15(2)3)9-14-13(10)12/h4-6,9,14H,7-8H2,1-3H3 checkY
  • Key:PQSFTUCFMWBITK-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

7,N,N-trimethyltryptamine (7,N,N-TMT), also known as7-methyl-DMT, is atryptaminederivative which acts as anagonist of5-HT2 receptors.[1][2][3] In animal tests, both 7-TMT and its 5-methoxy derivative5-MeO-7-TMT produced behavioural responses similar to those ofpsychedelic drugs such asDMT, but the larger 7-ethyl and 7-bromo derivatives of DMT did not produce psychedelic responses despite having higher 5-HT2 receptor affinityin vitro (cf.DOBU,DOAM).[4] 7-TMT also weakly inhibitsreuptake of serotonin but with little effect on dopamine or noradrenaline reuptake.[5]

See also

[edit]

References

[edit]
  1. ^Glennon RA, Liebowitz SM, Mack EC (August 1978). "Serotonin receptor binding affinities of several hallucinogenic phenylalkylamine and N,N-dimethyltryptamine analogues".Journal of Medicinal Chemistry.21 (8):822–5.doi:10.1021/jm00206a022.PMID 278843.
  2. ^Glennon RA, Gessner PK (April 1979). "Serotonin receptor binding affinities of tryptamine analogues".Journal of Medicinal Chemistry.22 (4):428–32.doi:10.1021/jm00190a014.PMID 430481.
  3. ^Lyon RA, Titeler M, Seggel MR, Glennon RA (January 1988). "Indolealkylamine analogs share 5-HT2 binding characteristics with phenylalkylamine hallucinogens".European Journal of Pharmacology.145 (3):291–7.doi:10.1016/0014-2999(88)90432-3.PMID 3350047.
  4. ^Glennon RA, Schubert E, Jacyno JM, Rosecrans JA (November 1980). "Studies on several 7-substituted N,N-dimethyltryptamines".Journal of Medicinal Chemistry.23 (11):1222–6.doi:10.1021/jm00185a014.PMID 6779006.
  5. ^Glennon RA, Martin B, Johnson KM, End D (January 1978). "7,N,N-Trimethyltryptamine: a selective inhibitor of synaptosomal serotonin uptake".Research Communications in Chemical Pathology and Pharmacology.19 (1):161–4.PMID 625585.

External links

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Tryptamines
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