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5F-PCN

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
5F-PCN
Legal status
Legal status
Identifiers
  • 1-(5-fluoropentyl)-N-(naphthalen-1-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC23H22FN3O
Molar mass375.447 g·mol−1
3D model (JSmol)
  • O=C(NC1=C(C=CC=C2)C2=CC=C1)C3=CN(CCCCCF)C4=C3C=NC=C4
  • InChI=1S/C23H22FN3O/c24-12-4-1-5-14-27-16-20(19-15-25-13-11-22(19)27)23(28)26-21-10-6-8-17-7-2-3-9-18(17)21/h2-3,6-11,13,15-16H,1,4-5,12,14H2,(H,26,28)
  • Key:BRRZRRZUERBDQL-UHFFFAOYSA-N

5F-PCN (also known as5F-MN-21) is an azaindole-basedsynthetic cannabinoid that is presumed to be a potentagonist of theCB1 receptor and has been sold online as adesigner drug.[1][2] It is closely related toNNE1. Given the known metabolic liberation (and presence as an impurity) ofamantadine in the related compoundAPINACA, it is suspected that metabolic hydrolysis of the amide group of 5F-PCN may release1-naphthylamine, a knowncarcinogen.

Legal status

[edit]

Sweden's public health agency suggested to classify 5F-PCN as hazardous substance on November 10, 2014.[3]

See also

[edit]

References

[edit]
  1. ^"5F-PCN". Cayman Chemical. Retrieved22 July 2015.
  2. ^Blaazer AR, Lange JH, van der Neut MA, Mulder A, den Boon FS, Werkman TR, et al. (October 2011). "Novel indole and azaindole (pyrrolopyridine) cannabinoid (CB) receptor agonists: design, synthesis, structure-activity relationships, physicochemical properties and biological activity".European Journal of Medicinal Chemistry.46 (10):5086–98.doi:10.1016/j.ejmech.2011.08.021.PMID 21885167.
  3. ^"Cannabinoider föreslås bli klassade som hälsofarlig vara". Folkhälsomyndigheten. Retrieved22 July 2015.
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