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| Formula | C23H21FN2O2 |
| Molar mass | 376.431 g·mol−1 |
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5F-PB-22 (5F-QUPIC orquinolin-8-yl 1-pentyfluoro-1H-indole-3-8-carboxylate) is adesigner drug which acts as acannabinoid agonist.[2] The structure of 5F-PB-22 appears to have been designed with an understanding ofstructure–activity relationships within the indole class of cannabinoids.[3]
5F-PB-22 acts as afull agonist with abinding affinity of 0.468 nM atCB1 and 0.633 nM atCB2cannabinoid receptors.[4]
As of October 2015 5F-PB-22 is a controlled substance in China.[5]
In January 2014, 5F-PB-22 was designated as aSchedule I controlled substance in the United States after several deaths were associated with its use.[6][7]
In the United Kingdom, 5F-PB-22 is now classified and controlled as aClass B drug, following the November 2016 amendment to theMisuse of Drugs Act 1971. Several other synthetic cannabinoids structurally related toJWH-018, like 5F-PB-22, were also classified in this amendment.[8]
