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| Formula | C22H26FN3O |
| Molar mass | 367.468 g·mol−1 |
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5F-CUMYL-PINACA (also known asSGT-25 and sometimes sold ine-cigarette form asC-Liquid)[1] is anindazole-3-carboxamide basedsynthetic cannabinoid.[2] 5F-CUMYL-PINACA acts as a potentagonist for thecannabinoid receptors, with the original patent claiming approximately 4x selectivity forCB1, having an EC50 of <0.1 nM for humanCB1 receptors and 0.37 nM for humanCB2 receptors.[3] In more recent assays using different techniques, 5F-CUMYL-PINACA was variously found to have an EC50 of 0.43 nM at CB1 and 11.3 nM at CB2, suggesting a somewhat higher CB1 selectivity of 26 times,[4] or alternatively 15.1 nM at CB1 and 34.8 nM at CB2 with only 2.3 times selectivity, however these figures cannot be directly compared due to the different assay techniques used in each case.[5]
In the United States, 5F-CUMYL-PINACA was temporarily emergency scheduled by the DEA in 2019.[6] and made a permanentSchedule I Controlled Substance on April 7, 2022.[7]Sweden's public health agency suggested classifying 5F-CUMYL-PINACA as a hazardous substance on November 10, 2014.[8]
